The effect of certain neurotransmitters on the analgesic action of enkephalinamide.


The effect of noradrenaline, dopamine, acetylcholine and 5-hydroxytryptamine on the analgesic action of enkephalinamide was studied and it was demonstrated that catecholamines and acetylcholine potentiated the analgesic action of enkephalinamide, while the effect of serotonin varied depending on the dose used. These results suggest that catecholamines, acetylcholine and 5-hydroxytryptamine can modulate the analgesic action of enkephalins.


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